(±) -PPCC

(±) -PPCC is a sigma-1 agonist that mainly interacts with sigma-1 receptors with Ki of 1.5 nM. (±) -PPCC has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats[1].

Product Specifications

CAS Number

[932736-90-8]

UNSPSC

12352005

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/racemic-ppcc.html

Smiles

COC([C@]1(C2=CC=C(C=C2)C)[C@@H](C1)CN3CCC(CC3)(C4=CC=CC=C4)O)=O

Molecular Formula

C24H29NO3

Molecular Weight

379.49

References & Citations

[1]Antonini V, et al. Anti-amnesic properties of (+/-) -PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J Neurochem. 2009 May;109 (3) :744-54.