ATP-15N5 (dilithium)
Product Specifications
UNSPSC Description
ATP-15N5 (Adenosine 5'-triphosphate-15N5) dilithium is 15N labeled ATP (HY-B2176). ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.
Target Antigen
Endogenous Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/atp-15n5-dilithium.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=P(O)(O[Li])OP(OP(OC[C@H]1O[C@@H]([15N]2C3=[15N]C=[15N]C([15NH2])=C3[15N]=C2)[C@H](O)[C@@H]1O)(O)=O)(O[Li])=O
Molecular Weight
524.01
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8.|[3]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404.|[4]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.|[5]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B2176S5/ATP-15N5-dilithium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B2176S5/ATP-15N5-dilithium-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Curated Selection
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