ATP-15N5 (dilithium)

ATP-15N5 (Adenosine 5'-triphosphate-15N5) dilithium is 15N labeled ATP (HY-B2176) . ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.

Product Specifications

Product Name Alternative

Adenosine 5'-triphosphate-15N5 (dilithium)

UNSPSC

12352005

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/atp-15n5-dilithium.html

Concentration

100 mM in 19.08 μL Tris HCl/H2O buffer pH=7.5

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=P(O)(O[Li])OP(OP(OC[C@H]1O[C@@H]([15N]2C3=[15N]C=[15N]C([15NH2])=C3[15N]=C2)[C@H](O)[C@@H]1O)(O)=O)(O[Li])=O

Molecular Formula

C10H14Li2 15N5O13P3

Molecular Weight

524.01

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35 (3) :852-8.|[3]M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112 (2) :358-404.|[4]Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514.|[5]Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8 (5) : e63759.