AMG 9090
AMG 9090 is characterized as a compound that acts as a partial agonist of rat TRPA1 channels, demonstrating pharmacological activity in pain and inflammation models. TRPA1 is pivotal in sensing reactive compounds, triggering pain responses in humans and rodents. AMG 9090, along with other trichloro (sulfanyl) ethyl benzamides (TCEB compounds), shows differential effects on human and rat TRPA1 channels: it acts as a potent antagonist of human TRPA1 activated by AITC and noxious cold, whereas it behaves as a partial agonist at rat TRPA1. This suggests AMG 9090's potential as a therapeutic agent targeting TRPA1-mediated pain and inflammation, with additional inhibitory activity against TRPM8 noted[1].
Product Specifications
CAS Number
118215-82-0
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/amg-9090.html
Smiles
ClC(Cl)(Cl)C(SC1=CC=C(Cl)C=C1)NC(C2=CC=CC=C2)=O
Molecular Formula
C15H11Cl4NOS
Molecular Weight
395.13
References & Citations
[1]Species-specific pharmacology of Trichloro (sulfanyl) ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Human IgM Immunoglobulin (ICO-30), CF488A conjugate, 0.1mg/mL
