BuChE-IN-12

BuChE-IN-12 is a selective BuChE inhibitor (IC50=0.52 µM) that acts via affecting CAS and PAS sites and has potential effects against oxidative stress. BuChE-IN-12 can be used in the study of Alzheimer's disease[1].

Product Specifications

CAS Number

[1363947-94-7]

UNSPSC

12352211

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/buche-in-12.html

Smiles

CC1=CC=C(NC2=C3C=CC=CC3=NC(NC4=CC=C(C)C=C4)=N2)C=C1

Molecular Formula

C22H20N4

Molecular Weight

340.42

References & Citations

[1]Sadeghian, et al. Synthesis, biological evaluation, molecular docking, and MD simulation of novel 2, 4-disubstituted quinazoline derivatives as selective butyrylcholinesterase inhibitors and antioxidant agents. Scientific Reports 14.1 (2024) : 15577.