4- (4-Fluorophenyl) benzoic acid
4- (4-Fluorophenyl) benzoic acid (Compoud 6) can bind to Bcl-2 with a KD value of 400 μM. 4- (4-Fluorophenyl) benzoic acid can be used to develope Bcl-2 selective anti-cancer agent[1].
Product Specifications
CAS Number
[5731-10-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/4-4-fluorophenyl-benzoic-acid.html
Purity
99.01
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(C1=CC=C(C2=CC=C(F)C=C2)C=C1)O
Molecular Formula
C13H9FO2
Molecular Weight
216.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Petros AM, et al. Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett. 2010 Nov 15;20 (22) :6587-91.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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