DNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R) -23a) is a DNMT1/HDAC dual inhibitor (HDAC1:IC50=0.05 μM), HDAC1 is a major HDAC isoform that interacts with DNMT1 in multiple protein complexes for transcriptional silencing of TSGs. DNMT1/HDAC-IN-1 can reshape the tumor immune microenvironment and induce tumor regression, and effectively reverse cancer-specific epigenetic abnormalities[1].
Product Specifications
UNSPSC
12352005
Target
DNA Methyltransferase; HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dnmt1-hdac-in-1.html
Smiles
CCC1=C(C(S[C@H](C2=CC=CC=C2)C(N)=O)=NC(N3CCC(CC3)CNCC4=CC=C(C=C4)/C=C/C(NO)=O)=C1C#N)C#N
Molecular Formula
C33H35N7O3S
Molecular Weight
609.74
References & Citations
[1]Chang Y, et al. Development of a First-in-Class DNMT1/HDAC Inhibitor with Improved Therapeutic Potential and Potentiated Antitumor Immunity[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1
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