Ajmaline (hydrochloride)
Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.
Product Specifications
CAS Number
[4410-48-4]
Product Name Alternative
Cardiorythmine (hydrochloride) ; (+) -Ajmaline (hydrochloride)
UNSPSC
12352005
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ajmaline-hydrochloride.html
Smiles
CN1[C@@]2([H])[C@]3([H])C[C@H]4[C@H](CC)[C@@H](N3[C@@H]5[C@H]4[C@H]([C@]2(C5)C6=C1C=CC=C6)O)O.Cl
Molecular Formula
C20H27ClN2O2
Molecular Weight
362.89
References & Citations
[1]Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Launched
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