PROTAC ALK degrader-1

PROTAC ALK degrader-1 (compound B1) is an ALK degrader based on PROTACs, with the DC50 of 26 nM in H3122 EML4-ALK. PROTAC ALK degrader-1 can be used to synthesis PROTAC ALK degrader-2 (HY-161750) with superior bioavailability[1].

Product Specifications

CAS Number

[3049802-45-8]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-alk-degrader-1.html

Smiles

CC(C)S(C1=C(NC2=C(Cl)C=NC(NC3=C(OC(C)C)C=C(C4CCN(CC(NCC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)=O)CC4)C(C)=C3)=N2)C=CC=C1)(=O)=O

Molecular Formula

C47H55ClN10O9S

Molecular Weight

971.52

References & Citations

[1]Shirui Wang, et al. Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation. J Med Chem. 2024 Jun 27;67 (12) :9842-9856.