Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

JJKK 048

JJKK 048 is a highly selective and potent monoacylglycerol lipase (MAGL) inhibitor with IC50 values of 214 pM, 275 pM and 363 pM for human, rat, and mouse MAGL. JJKK 048 displays low cross-reactivity with other endocannabinoid targets. JJKK 048 can be used in the research of diseases such as cancer, neurodegenerative diseases, and pain[1][2].

Product Specifications

CAS Number

1515855-97-6

UNSPSC

12352005

Hazard Statement

H315, H319

Target

MAGL

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/JJKK_048.html

Purity

99.55

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N1CCC(C(C2=CC=C(OCO3)C3=C2)C4=CC=C(OCO5)C5=C4)CC1)N6N=CN=C6

Molecular Formula

C23H22N4O5

Molecular Weight

434.44

Precautions

H315, H319

References & Citations

[1]Aaltonen N, et al. In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis- (benzo[d][1,3]dioxol-5-yl) methyl]-piperidin-1-yl} (1H-1,2,4-triazol-1-yl) methanone (JJKK-048) . J Pharmacol Exp Ther. 2016 Oct;359 (1) :62-72.|[2]Aaltonen N, et al. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20 (3) :379-90.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Spectrin Alpha 1 (Erythrocyte Marker) (rSPTA1/1833), CF640R conjugate, 0.1mg/mL
BNC402556-500 1x 500 µL

Spectrin Alpha 1 (Erythrocyte Marker) (rSPTA1/1833), CF640R conjugate, 0.1mg/mL

Sign In for Pricing
View Details
APOB48R (APOBR) Mouse Monoclonal Antibody [Clone ID: OTI6A6]
CF807166 100 µg

APOB48R (APOBR) Mouse Monoclonal Antibody [Clone ID: OTI6A6]

Sign In for Pricing
View Details
Fetuin A (AHSG) (C-term) Rabbit Polyclonal Antibody
AP50120PU-N 400 µL

Fetuin A (AHSG) (C-term) Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
Chlorophosphonazo III (Technical Grade)
TRC-C375385-250MG 250 mg

Chlorophosphonazo III (Technical Grade)

Sign In for Pricing
View Details
LINC01106 Human qPCR Primer Pair (NM_152518)
HP217773 200 Reactions

LINC01106 Human qPCR Primer Pair (NM_152518)

Sign In for Pricing
View Details
Human VN1R3 activation kit by CRISPRa
GA117317 1 Kit

Human VN1R3 activation kit by CRISPRa

Sign In for Pricing
View Details