PF-04628935
PF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC50 of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research[1][2].
Product Specifications
CAS Number
[1383719-97-8]
Product Name Alternative
2'-3'-cyclic GMP-AMP
UNSPSC
12352005
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-04628935.html
Purity
99.1
Solubility
10 mM in DMSO
Smiles
CC1=CN2C(S1)=NC(CC(N3CCC4(CN(C4)CC5=CC=C(C=C5Cl)N6N=CC=N6)CC3)=O)=C2
Molecular Formula
C24H26ClN7OS
Molecular Weight
496.03
References & Citations
[1]Kung DW, et, al. Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett. 2012 Jul 1;22 (13) :4281-7.|[2]Cavalcante DP, et, al. Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats. Behav Brain Res. 2019 Jun 3;365:178-184.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GHSR1a
Available Sizes
Curated Selection
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