PF-04628935
Product Specifications
Product Name Alternative
2'-3'-cyclic GMP-AMP
UNSPSC Description
PF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC50 of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research[1][2].
Target Antigen
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-04628935.html
Solubility
10 mM in DMSO
Smiles
CC1=CN2C(S1)=NC(CC(N3CCC4(CN(C4)CC5=CC=C(C=C5Cl)N6N=CC=N6)CC3)=O)=C2
Molecular Weight
496.03
References & Citations
[1]Kung DW, et, al. Identification of spirocyclic piperidine-azetidine inverse agonists of the ghrelin receptor. Bioorg Med Chem Lett. 2012 Jul 1;22(13):4281-7.|[2]Cavalcante DP, et, al. Role of dorsal raphe nucleus GHS-R1a receptors in the regulation of inhibitory avoidance and escape behaviors in rats. Behav Brain Res. 2019 Jun 3;365:178-184.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116625/PF-04628935-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116625/
Clinical Information
No Development Reported
CAS Number
1383719-97-8
Available Sizes
Curated Selection
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