Pinocembrin

Pinocembrin is a natural product isolated from the leaves of A. zerumbet. It displays enhanced alkaline phosphatase (ALP) activity and mineralization and increased mRNA expression of osteoblast-related genes Alp and Osteocalcin (Ocn) in MC3T3-E1 cells. Pinocembrin increases the mRNA expression of Runx2 and Osterix, which are important transcription factors in osteoblast differentiation, and the mRNA expression of Dlx5 and Msx2, which are enhancers of these transcription factors. Pinocembrin induces ER stress mediated apoptosis and suppress autophagy in melanoma, indicating its application potential for melanoma therapy.