SR 49059
SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM[1].
Product Specifications
CAS Number
150375-75-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/SR_49059.html
Purity
99.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C([C@@]2(O)C3=CC(Cl)=CC=C3N(S(=O)(C4=CC(OC)=C(OC)C=C4)=O)[C@]2(C(N5[C@H](C(N)=O)CCC5)=O)[H])C=CC=C1
Molecular Formula
C28H27Cl2N3O7S
Molecular Weight
620.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Serradeil-Le Gal C, et al. Effect of SR-49059, a vasopressin V1a antagonist, on human vascular smooth muscle cells. Am J Physiol. 1995 Jan;268 (1 Pt 2) :H404-10.|[2]Shuaib A, et al. Effects of nonpeptide V (1) vasopressin receptor antagonist SR-49059 on infarction volume and recovery of function in a focal embolic stroke model. Stroke. 2002 Dec;33 (12) :3033-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
V1a Receptor
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
294457-01 250 mg
Phenyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-a-D-thiomannopyranoside
Sign In for Pricing
View Details 294457-02 500 mg
Phenyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-a-D-thiomannopyranoside
Sign In for Pricing
View Details 294457-03 1 g
Phenyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-a-D-thiomannopyranoside
Sign In for Pricing
View Details 294457-04 2 g
Phenyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-a-D-thiomannopyranoside
Sign In for Pricing
View Details