SR 49059

SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM[1].

Product Specifications

CAS Number

[150375-75-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Vasopressin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/SR_49059.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=C([C@@]2(O)C3=CC(Cl)=CC=C3N(S(=O)(C4=CC(OC)=C(OC)C=C4)=O)[C@]2(C(N5[C@H](C(N)=O)CCC5)=O)[H])C=CC=C1

Molecular Formula

C28H27Cl2N3O7S

Molecular Weight

620.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Serradeil-Le Gal C, et al. Effect of SR-49059, a vasopressin V1a antagonist, on human vascular smooth muscle cells. Am J Physiol. 1995 Jan;268 (1 Pt 2) :H404-10.|[2]Shuaib A, et al. Effects of nonpeptide V (1) vasopressin receptor antagonist SR-49059 on infarction volume and recovery of function in a focal embolic stroke model. Stroke. 2002 Dec;33 (12) :3033-7.