SR 49059
SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a Ki vaule of 1.4 nM[1].
Product Specifications
CAS Number
150375-75-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/SR_49059.html
Purity
99.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C([C@@]2(O)C3=CC(Cl)=CC=C3N(S(=O)(C4=CC(OC)=C(OC)C=C4)=O)[C@]2(C(N5[C@H](C(N)=O)CCC5)=O)[H])C=CC=C1
Molecular Formula
C28H27Cl2N3O7S
Molecular Weight
620.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Serradeil-Le Gal C, et al. Effect of SR-49059, a vasopressin V1a antagonist, on human vascular smooth muscle cells. Am J Physiol. 1995 Jan;268 (1 Pt 2) :H404-10.|[2]Shuaib A, et al. Effects of nonpeptide V (1) vasopressin receptor antagonist SR-49059 on infarction volume and recovery of function in a focal embolic stroke model. Stroke. 2002 Dec;33 (12) :3033-7.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
V1a Receptor
Available Sizes
Frequently Asked Questions
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