CD6 (Negative Marker of T-regulatory Cells) (SPV-L14), 1mg/mL

CD6 is a type I transmembrane glycoprotein that contains a 24-amino acid signal sequence, three extracellular scavenger receptor cysteine-rich (SRCR) domains, a membrane-spanning domain and a 44-amino acid cytoplasmic domain. The CD6 glycoprotein is tyrosine phosphorylated during TCR-mediated T cell activation. CD6 shows significant homology to CD5. CD6 is present on mature thymocytes, peripheral T cells and a subset of B cells. Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease.

Product Specifications

CAS Number

9007-83-4

Synonyms

T12; TP120

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CD6

Gene ID

923

NCBI Gene ID

744366

UniProt

P30203

Swiss Prot

P30203

Host

Mouse

Species Reactivity

Human,Mouse

Reactivity

CD6

Immunogen

CD8 cytotoxic T-cell clone

Target Antigen

CD6

Clonality

Monoclonal

Clone

SPV-L14

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (verified) |Flow, surface (published) |Functional studies (published) |IF (published) |IF (verified)

Field of Research

Immunology

Positive Control

CCRF-CEM, Jurkat cells, Tonsil

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

90-130 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. PNAS USA (1987) 84: 3861-3865. (Flow, surface; IF) J Inv Dermatol (1994) 102(6): 833-837. (Flow, surface) J Immunol (2006) 177:1152-1159. (functional studies) Nat Immunol (2014) 15(4): 384-392. (functional studies)