Recombinant CDK9 / CyclinT1 Protein Complex

<strong>Recombinant CDK9 / CyclinT1 Protein Complex</strong>_x000D_ <strong>Catalog number:</strong> B2017484_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 20 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> CDK9: 42.76 kDa, Cyclin-T1:81.95 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Cyclin Dependent Kinase 9, TAK, PITALRE, CDC2L4, C-2k, Cell Division Cycle 2-Like Protein Kinase 4, CTK1_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Napolitano G, Majello B, Lania L. Catalytic activity of Cdk9 is required for nuclear co-localization of the Cdk9/cyclin T1 (P-TEFb) complex J Cell Physiol. 2003 Oct;197(1):1-7._x000D_ 2: Brès V, Gomes N, Pickle L, Jones KA. A human splicing factor, SKIP, associates with P-TEFb and enhances transcription elongation by HIV-1 Tat Genes Dev. 2005 May 15;19(10):1211-26._x000D_ 3: Bai J, Sui J, Zhu RY, Tallarico AS, Gennari F, Zhang D, Marasco WA. Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies J Biol Chem. 2003 Jan 17;278(3):1433-42._x000D_ 4: Winter GE, Mayer A, Buckley DL, Erb MA, Roderick JE, Vittori S, Reyes JM, di Iulio J, Souza A, Ott CJ, Roberts JM, Zeid R, Scott TG, Paulk J, Lachance K, Olson CM, Dastjerdi S, Bauer S, Lin CY, Gray NS, Kelliher MA, Churchman LS, Bradner JE. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment Mol Cell. 2017 Jul 6;67(1):5-18.e19._x000D_ 5: Chu YY, Chen MK, Wei Y, Lee HH, Xia W, Wang YN, Yam C, Hsu JL, Wang HL, Chang WC, Yamaguchi H, Jiang Z, Liu C, Li CF, Nie L, Chan LC, Gao Y, Wang SC, Liu J, Westin SN, Lee S, Sood AK, Yang L, Hortobagyi GN, Yu D, Hung MC. Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex Nat Cancer. 2022 Oct;3(10):1211-1227._x000D_ 6: Pinhero R, Yankulov K. Expression and Purification of Recombinant CDKs: CDK7, CDK8, and CDK9 Methods Mol Biol. 2016;1336:13-28._x000D_ 7: Cress WD. A stitch in time and CDK9 Cell Cycle. 2017 May 3;16(9):823-824._x000D_ 8: Alfano L, Iannuzzi CA, Barone D, Forte IM, Ragosta MC, Cuomo M, Mazzarotti G, Dell'Aquila M, Altieri A, Caporaso A, Roma C, Marra L, Boffo S, Indovina P, De Laurentiis M, Giordano A. CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice Oncogene. 2024 Apr;43(17):1263-1273._x000D_ 9: Canduri F, Perez PC, Caceres RA, de Azevedo WF Jr. CDK9 a potential target for drug development Med Chem. 2008 May;4(3):210-8._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/32934219">10: Štětková M, Growková K, Fojtík P, Valčíková B, Palušová V, Verlande A, Jorda R, Kryštof V, Hejret V, Alexiou P, Rotrekl V, Uldrijan S. CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells Cell Death Dis. 2020 Sep 15;11(9):754. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant CDK9 / CyclinT1 Protein Complex can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>