Flavone
Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21waf1, PIG3) . Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer[1][2][3].
Product Specifications
CAS Number
525-82-6
Product Name Alternative
2-Phenyl-4-chromone
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H401
Target
Apoptosis; Caspase; CDK
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flavone.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC=CC=C13
Molecular Formula
C15H10O2
Molecular Weight
222.24
Precautions
H315, H319, H335, H401
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 9; CDK1
Available Sizes
Frequently Asked Questions
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