Flavone

Flavone is an anti-tumor compound that targets cell cycle regulatory proteins (such as cyclin B1) and apoptosis-related factors (such as p21waf1, PIG3) . Flavone selectively induces mitochondrial-mediated apoptosis pathways in tumor cells, inhibits cyclin B1 protein expression, upregulates p21waf1, and activates p63/p73 proteins. Flavone has immunomodulatory functions that enhance natural killer cell (NK cell) activity and lymphocyte proliferation. Flavone is used in cancer research, especially for its inhibitory potential in solid tumor models such as esophageal cancer and liver cancer[1][2][3].

Product Specifications

CAS Number

[525-82-6]

Product Name Alternative

2-Phenyl-4-chromone

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H401

Target

Apoptosis; Caspase; CDK

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/flavone.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=CC=CC=C13

Molecular Formula

C15H10O2

Molecular Weight

222.24

Precautions

H315, H319, H335, H401

References & Citations

[1]Chirumbolo S. The role of quercetin, flavonols and flavones in modulating inflammatory cell function. Inflamm Allergy Drug Targets. 2010 Sep;9 (4) :263-85.|[2]Zhang Q, et al. Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis. Toxicol In Vitro. 2009 Aug;23 (5) :797-807.|[3]Liu S, et al. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int Immunopharmacol. 2006 Sep;6 (9) :1387-93.