Promazine

Promazine (Romtiazin) is an antipsychotic and a dopamine receptor D2 antagonist. Promazine inhibits dopaminergic neurotransmission[1][2].

Product Specifications

CAS Number

[58-40-2]

Product Name Alternative

Romtiazin; Ampazine; Berophen

UNSPSC

12352005

Hazard Statement

H302

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/promazine.html

Solubility

10 mM in DMSO

Smiles

CN(C)CCCN1C2=C(C=CC=C2)SC3=CC=CC=C13

Molecular Formula

C17H20N2S

Molecular Weight

284.42

Precautions

P264-P270-P330-P501

References & Citations

[1]Myers PR, et al. Characterization of a depolarizing dopamine response in a vertebrate neuronal somatic cell hybrid. J Cell Physiol. 1977;91 (1) :103-118. |[2]Gareri P, et al. Conventional and atypical antipsychotics in the elderly : a review. Clin Drug Investig. 2003;23 (5) :287-322. |[3]Tatsumi M, et al. Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol. 1999;368 (2-3) :277-283.