4-Hydroxyphenylglyoxylate

4-Hydroxyphenylglyoxylate (4-Hydroxyphenylglyoxylic acid) is an inhibitor of carnitine palmitoyltransferase I (CPT I) . 4-Hydroxyphenylglyoxylate can be used to study sensitivity changes in CPT I of liver mitochondria and fatty acid oxidation by isolated hepatocytes. 4-Hydroxyphenylglyoxylate can inhibits fatty acid oxidation[1].

Product Specifications

CAS Number

[15573-67-8]

Product Name Alternative

4-Hydroxyphenylglyoxylic acid; 4-HPGA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Acyltransferase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-hydroxyphenylglyoxylate.html

Purity

99.34

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C1=C(C=CC(=C1)O)C(=O)C(=O)O

Molecular Formula

C8H6O4

Molecular Weight

166.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Stephens TW, et al. Effect of starvation and diabetes on the sensitivity of carnitine palmitoyltransferase I to inhibition by 4-hydroxyphenylglyoxylate. Biochem J. 1987 Apr 15;243 (2) :405-12.