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Physostigmine (salicylate) (Standard)

Selected Variant

HY-B1266R-01

Size: 5 mg

Physostigmine (salicylate) (Standard) is the analytical standard of Physostigmine (salicylate) . This product is intended for research and analytical applications. Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4].

Product Specifications

CAS Number

57-64-7

Product Name Alternative

Eserine (salicylate) (Standard)

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Reference Standards

Type

Reference Standards

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/physostigmine-salicylate-standard.html

Smiles

O=C(O)C1=CC=CC=C1O.O=C(OC2=CC3=C(N(C)[C@]4([H])[C@@]3(C)CCN4C)C=C2)NC

Molecular Formula

C22H27N3O5

Molecular Weight

413.47

References & Citations

[1]Jonathan D Kenny, et al. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 Nov;123 (5) :1210-1219.|[2]Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42 (3) :188‐189.|[3]Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl) . 2005;181 (1) :145‐152.|[4]Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings?. Curr Opin Pediatr. 2007;19 (2) :201‐205.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Available Sizes

Price

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