E6 Berbamine
E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM) -dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM[1]. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells[2].
Product Specifications
CAS Number
114784-59-7
Product Name Alternative
Berbamine p-nitrobenzoate
UNSPSC
12352005
Target
Calmodulin
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e6-berbamine.html
Smiles
COC1=C(OC2=CC3=C(C=C2OC)CCN4C)C5=C(C=C1OC)CCN(C)[C@@]5(CC6=CC=C(C(OC7=CC=C(C=C7)C[C@@]34[H])=C6)OC(C8=CC=C(C=C8)[N+]([O-])=O)=O)[H]
Molecular Formula
C44H43N3O9
Molecular Weight
757.83
References & Citations
[1]Z Y Hu, et al. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Biochem Pharmacol. 1992 Oct 20;44 (8) :1543-7. |[2]Jinwen Xie, et al. Berbamine derivatives: a novel class of compounds for anti-leukemia activity. Eur J Med Chem. 2009 Aug;44 (8) :3293-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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