E6 Berbamine

E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM) -dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM[1]. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells[2].

Product Specifications

CAS Number

[114784-59-7]

Product Name Alternative

Berbamine p-nitrobenzoate

UNSPSC

12352005

Target

Calmodulin

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e6-berbamine.html

Smiles

COC1=C(OC2=CC3=C(C=C2OC)CCN4C)C5=C(C=C1OC)CCN(C)[C@@]5(CC6=CC=C(C(OC7=CC=C(C=C7)C[C@@]34[H])=C6)OC(C8=CC=C(C=C8)[N+]([O-])=O)=O)[H]

Molecular Formula

C44H43N3O9

Molecular Weight

757.83

References & Citations

[1]Z Y Hu, et al. Interaction of berbamine compound E6 and calmodulin-dependent myosin light chain kinase. Biochem Pharmacol. 1992 Oct 20;44 (8) :1543-7. |[2]Jinwen Xie, et al. Berbamine derivatives: a novel class of compounds for anti-leukemia activity. Eur J Med Chem. 2009 Aug;44 (8) :3293-8.