PF-1355
PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.
Product Specifications
CAS Number
1435467-38-1
Product Name Alternative
PF-06281355
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/PF-1355.html
Purity
99.80
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N)CN(C(N1)=S)C(C2=CC(OC)=CC=C2OC)=CC1=O
Molecular Formula
C14H15N3O4S
Molecular Weight
321.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Zheng W, et al. PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015 May;353 (2) :288-98
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC470994-100 1x 100 µL
TNF alpha (J2D10), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC470775-500 1x 500 µL
Pgp9.5 (UCHL-1) (UCHL1/775), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC941101-100 1x 100 µL
MCAM / MUC18 / Mucin 18 / CD146 (MCAM/1101), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940952-100 1x 100 µL
Human IgG Immunoglobulin (B33/20), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details