PF-1355
PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.
Product Specifications
CAS Number
[1435467-38-1]
Product Name Alternative
PF-06281355
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/PF-1355.html
Purity
99.80
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N)CN(C(N1)=S)C(C2=CC(OC)=CC=C2OC)=CC1=O
Molecular Formula
C14H15N3O4S
Molecular Weight
321.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Zheng W, et al. PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis. J Pharmacol Exp Ther. 2015 May;353 (2) :288-98
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
NBP3-28332-1mg 1 mg
CHO Monoclonal IL-20R alpha Antibody (Cheng Kung U. patent anti-IL-20R1) - Humanized - (Dry Ice)
Ask
View Details 
