CD5 (Mantle Cell Lymphoma Marker) (B-B8), 0.2mg/mL

This antibody recognizes a 67 kDa transmembrane protein which is identified as CD5. The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms. Note that this MAb is not suitable for frozen tissues.

Product Specifications

CAS Number

9007-83-4

Synonyms

CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CD5

Gene ID

921

NCBI Gene ID

58685

UniProt

P06127

Swiss Prot

P06127

Host

Mouse

Species Reactivity

Human

Reactivity

CD5

Immunogen

T cells activated with PHA

Target Antigen

CD5

Clonality

Monoclonal

Clone

B-B8

Type

Primary

Source

Animal

Origin

Animal

Applications

Functional studies (published) |Flow, surface (expected) |IF (expected)

Field of Research

Immunology

Positive Control

293T, Ramos, or MOLT-4 Cells. Tonsil.

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

67 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Inf Immunity (1996) 64(5): 1595-1599. (cell depletion) Br J Haematol (2013) 163: 182-193. (antibody internalization)