Cbl-b-IN-18
Cbl-b-IN-18 (compound 51) is an inhibitor of the E3 ligase Casitas B-lineage lymphoma proto-oncogene B (CPL-B) . Cbl-b-IN-18 inhibits the phosphorylation of CPL-B (IC50[1].
Product Specifications
UNSPSC
12352005
Target
E1/E2/E3 Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cbl-b-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=NC(C3CC3)=CC(C4=CC=C(F)C=C4C5=NN=CN5C)=C2)C=NC6=C1C=C(CN7C[C@@H](C)CCC7)C=C6C(F)(F)F
Molecular Formula
C33H31F4N7O
Molecular Weight
617.64
References & Citations
[1]Murugan CHINNAPATTU, et al. Bicyclic heterocyclic compounds as cbl-b inhibitors. Worldwide, WO2024062363A1. 2023-09-18
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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