16,16-Dimethyl prostaglandin E2

16,16-Dimethyl prostaglandin E2 (16,16-dimethyl PGE2) is an orally active vertebrate Hematopoietic stem cells (HSCs) homeostasis critical regulator. 16,16-Dimethyl prostaglandin E2 can act through EP2/EP4 and has an interaction with the Wnt pathway[1][2].

Product Specifications

CAS Number

[39746-25-3]

Product Name Alternative

16,16-dimethyl PGE2

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

Prostaglandin Receptor; Wnt

Type

Reference compound

Related Pathways

GPCR/G Protein; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/16-16-dimethyl-prostaglandin-e2.html

Concentration

26.28 mM * 5 mL in Methyl acetate

Purity

99.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCC(C)([C@@H](/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)C(C[C@H]1O)=O)O)C

Molecular Formula

C22H36O5

Molecular Weight

380.52

Precautions

H225, H319, H336

References & Citations

[1]Hagedorn EJ, et al. Getting more for your marrow: boosting hematopoietic stem cell numbers with PGE2. xp Cell Res. 2014 Dec 10;329 (2) :220-6.|[2]Roulis M, et al. Intestinal myofibroblast-specific Tpl2-Cox-2-PGE2 pathway links innate sensing to epithelial homeostasis. Proc Natl Acad Sci U S A. 2014 Oct 28;111 (43) :E4658-67.