Sappanone A

Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular [1][2][3][4][5].

Product Specifications

CAS Number

[102067-84-5]

UNSPSC

12352005

Target

Akt; COX; ERK; Interleukin Related; JNK; Keap1-Nrf2; NF-κB; NO Synthase; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK; Phosphodiesterase (PDE) ; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sappanone-a.html

Concentration

10mM

Purity

99.87

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1/C(COC2=CC(O)=CC=C12)=C/C3=CC=C(O)C(O)=C3

Molecular Formula

C16H12O5

Molecular Weight

284.26

References & Citations

[1]Lee S, et, al. Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Int Immunopharmacol. 2015 Sep;28 (1) :328-36. |[2]Wang YZ, et al. Sappanone A: A natural PDE4 inhibitor with dual anti-inflammatory and antioxidant activities from the heartwood of Caesalpinia sappan L. J Ethnopharmacol. 2023 Mar 25;304:116020.|[3]Choo YY, et al. Sappanone A inhibits RANKL-induced osteoclastogenesis in BMMs and prevents inflammation-mediated bone loss. Int Immunopharmacol. 2017 Nov;52:230-237. |[4]Shi X, et al. Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2. Drug Des Devel Ther. 2020 Jan 8;14:61-71.|[5]Wang Z, et al. Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis via the NF-κB signaling pathway. Front Pharmacol. 2022 Aug 16;13:953004.