Totrombopag (choline)
Totrombopag (SB-559448) choline is an orally effective thrombopoietin receptor (TpoR) agonist. By activating TpoR, Totrombopag choline initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5, a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag choline can be used to study platelet production and megakaryocyte biology[1].
Product Specifications
CAS Number
851606-62-7
Product Name Alternative
SB-559448 (choline)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Thrombopoietin Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/totrombopag-choline.html
Smiles
O=C1N(C2=CC=C(C)C(C)=C2)N=C(C1/N=N/C3=C(O)C(C4=CC(C5=NN=N[N-]5)=CC=C4)=CC=C3)C.OCC[N+](C)(C)C
Molecular Formula
C30H35N9O3
Molecular Weight
569.66
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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