LRH-1 modulator-1

LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa[1].

Product Specifications

CAS Number

[2244781-29-9]

UNSPSC

12352005

Target

Interleukin Related; Orphan Nuclear Receptor; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lrh-1-modulator-1.html

Purity

98.58

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

C=C(C1=CC=CC=C1)[C@]([C@](C2)([H])[C@H]3N[S](N)(=O)=O)(CC3)C(C4=CC=CC=C4)=C2CCCCCC

Molecular Formula

C28H36N2O2S

Molecular Weight

464.66

References & Citations

[1]Mays SG, et al. Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J Med Chem. 2019 Dec 26;62 (24) :11022-11034.