Sipatrigine

Sipatrigine (619C89), a neuroprotective agent, is a glutamate release inhibitor, voltage-dependent sodium channel and calcium channel inhibitor, penetrating the central nervous system. Has the potential in the study for focal cerebral ischemia and stroke[1][2].

Product Specifications

CAS Number

[130800-90-7]

Product Name Alternative

619C89; BW 619C89

UNSPSC

12352005

Target

Calcium Channel; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sipatrigine.html

Concentration

10mM

Purity

99.63

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

NC1=NC(N2CCN(C)CC2)=NC=C1C3=CC(Cl)=CC(Cl)=C3Cl

Molecular Formula

C15H16Cl3N5

Molecular Weight

372.68

References & Citations

[1]Leach MJ, et al. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke. 1993 Jul;24 (7) :1063-7.|[2]Atticus H. Hainsworth, et al. Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor. CNS Drug Reviews. Vol. 6, No. 2, pp. 111-134.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

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