Aristolochic acid D (Standard)

Aristolochic acid D (Standard) (Aristolochic acid-IVa (Standard) ) is the analytical standard of Aristolochic acid D (HY-N1465) . This product is intended for research and analytical applications. Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 (IC50: 4.673 μM) and CDK2 (IC50: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases[1][2].

Product Specifications

CAS Number

[17413-38-6]

Product Name Alternative

Aristolochic acid-IVa (Standard)

UNSPSC

12352005

Target

CDK; Interleukin Related; Phosphodiesterase (PDE) ; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aristolochic-acid-d-standard.html

Smiles

O=C(C1=C2C([N+]([O-])=O)=CC3=C(OC)C=C(O)C=C3C2=C(OCO4)C4=C1)O

Molecular Formula

C17H11NO8

Molecular Weight

357.27

References & Citations

[1]Kupchan SM, et al. The isolation and structural elucidation of novel derivatives of aristolochic acid from Aristolochia indica. J Org Chem. 1968 Oct;33 (10) :3735-8.|[2]Balachandran P, et al. Structure activity relationships of aristolochic acid analogues: toxicity in cultured renal epithelial cells. Kidney Int. 2005 May;67 (5) :1797-805.