Thalidomide-Piperazine 5-fluoride (hydrochloride)
Thalidomide-Piperazine 5-fluoride hydrochloride is a derivative of cereblon (CRBN) inhibitor Thalidomide (HY-14658), which can be used as ligands for E3 ubiquitin ligase (Ligands for E3 Ligase) for PROTACs Synthesis[1].
Product Specifications
CAS Number
[2222114-23-8]
UNSPSC
12352005
Hazard Statement
H302, H361
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-piperazine-5-fluoride-hydrochloride.html
Purity
98.91
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(CC1)N2C(C3=CC(F)=C(N4CCNCC4)C=C3C2=O)=O)=O.Cl
Molecular Formula
C17H18ClFN4O4
Molecular Weight
396.80
Precautions
H302, H361
References & Citations
[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
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