Naltriben (mesylate)
Product Specifications
UNSPSC Description
Naltriben mesylate is a potent δ2-opioid receptor antagonist and a TRPM7 activator. Naltriben mesylate shows Ki values of 0.013 nM, 19 nM and 152 nM for δ, μ and κ receptors, respectively. Naltriben mesylate enhances glioblastoma cell migration and invasion. Naltriben mesylate can be used in research into neurological diseases and cancer[1][2].
Target Antigen
Opioid Receptor; TRP Channel
Type
Reference compound
Related Pathways
GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/naltriben-mesylate.html
Purity
99.65
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CS(=O)(O)=O.O[C@@]1(CC(C(C=CC=C2)=C2O3)=C3[C@]4([H])OC5=C6O)[C@]74C5=C(C=C6)C[C@@]1([H])N(CC8CC8)CC7
Molecular Weight
511.59
References & Citations
[1]Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav. 1995;52(1):153-159. |[2]Rawls SM, et al. Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats. Brain Res. 2005;1049(1):61-69.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101302/Naltriben-mesylate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101302/Naltriben-mesylate-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
122517-78-6
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