Naltriben (mesylate)

Naltriben mesylate is a potent δ2-opioid receptor antagonist and a TRPM7 activator. Naltriben mesylate shows Ki values of 0.013 nM, 19 nM and 152 nM for δ, μ and κ receptors, respectively. Naltriben mesylate enhances glioblastoma cell migration and invasion. Naltriben mesylate can be used in research into neurological diseases and cancer[1][2].

Product Specifications

CAS Number

[122517-78-6]

UNSPSC

12352005

Target

Opioid Receptor; TRP Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/naltriben-mesylate.html

Purity

99.65

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CS(=O)(O)=O.O[C@@]1(CC(C(C=CC=C2)=C2O3)=C3[C@]4([H])OC5=C6O)[C@]74C5=C(C=C6)C[C@@]1([H])N(CC8CC8)CC7

Molecular Formula

C27H29NO7S

Molecular Weight

511.59

References & Citations

[1]Krishnan-Sarin S, Portoghese PS, Li TK, Froehlich JC. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Pharmacol Biochem Behav. 1995;52 (1) :153-159. |[2]Rawls SM, et al. Brain delta2 opioid receptors mediate SNC-80-evoked hypothermia in rats. Brain Res. 2005;1049 (1) :61-69.