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BI-11634

BI-11634 is a factor Xa inhibitor. BI-11634 is metabolized by CYP3A4 to form one major metabolite and this reaction is inhibited by Quinidine (HY-B1751H) with a Ki of 7 µM[1].

Product Specifications

CAS Number

[1622159-00-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Factor Xa

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bi-11634.html

Smiles

O=C(C1=CC=C(C(C)=C1)N2C(COCC2)=O)N[C@@H](COC)C3=NC4=CC=C(C=C4[N-]3)Cl.[Na+]

Molecular Formula

C22H22ClN4NaO4

Molecular Weight

464.88

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Mathur A, et al. Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine? Drug Metabol Drug Interact. 2013;28 (4) :239-46.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Curated Selection

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