Tacalcitol

Tacalcitol (1,24 (R) -Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) can promote normal bone growth by regulating calcium ions. Tacalcitol inhibits cancer cell proliferation and migration. Tacalcitol can be used in the research of inflammation, cancer, and skin diseases[1][2][3][4][5].

Product Specifications

CAS Number

[57333-96-7]

Product Name Alternative

1,24 (R) -Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3

UNSPSC

12352211

Hazard Statement

H300

Target

Interleukin Related; VD/VDR

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Tacalcitol.html

Purity

99.71

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](CC[C@H](C(C)C)O)C)CCC/2)[H])O)O

Molecular Formula

C27H44O3

Molecular Weight

416.64

Precautions

H300

References & Citations

[1]Rostkowska-Nadolska B, et al. Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures. Adv Med Sci. 2010;55 (1) :86-92.|[2]Kobayashi T, et al. 1 alpha,24R-dihydroxyvitamin D3 has an ability comparable to that of 1 alpha,25-dihydroxyvitamin D3 to induce keratinocyte differentiation. J Dermatol. 1990 Nov;17 (11) :707-9.|[3]Matsumoto K, et al. K. Effect of 1,24R-dihydroxyvitamin D3 on the growth of human keratinocytes. J Dermatol. 1990 Feb;17 (2) :97-103.|[4]Emanuelsson I, et al. Vitamin D Analogues Tacalcitol and Calcipotriol Inhibit Proliferation and Migration of T98G Human Glioblastoma Cells. Basic Clin Pharmacol Toxicol. 2018 Aug;123 (2) :130-136.|[5]Sato H, et al. Pharmacological profiles of high-concentration (20 microg/g) tacalcitol ointment: effects on cutaneous inflammation, epidermal proliferation, and differentiation in mice. J Dermatol. 2003 Jul;30 (7) :510-24.