Anti-Interleukin-22 Receptor (IL-22R) (NT) Antibody

Rabbit Polyclonal Antibody specific to IL-22R (NT)

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

IL-22 receptor subunit α-1, IL-22R-α-1, IL-22RA1, Cytokine receptor class-II member 9, Cytokine receptor family 2 member 9, CRF2-9, ZcytoR11

Gene Name

IL22RA1

NCBI Gene ID

UniProt

Q8N6P7

Cellular Locus

Membrane; Single-pass type I membrane protein.

Host

Rabbit

Reactivity

Human

Immunogen

Peptide corresponding to aa 31-46 of human IL-22R precursor.

Target Antigen

Interleukin-22 receptor subunit α-1

Target

Interleukin-22 Receptor (IL-22R) (NT)

Clonality

Polyclonal

Type

Antibody

Applications

ELISA, WB, IHC-P, ICC, IF

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by peptide immuno-affinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {PubMed:11035029, PubMed:11564763, PubMed:11706020, PubMed:12351624, PubMed:12941841, PubMed:17204547}.

Additionnal Information

Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 62 kD is detected. <br><br>Positive control: HepG2 cell lysate.

Storage Conditions

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Specificity

This antibody recognizes an epitope at the N-terminus of human IL-22R, the receptor for IL-22. IL-22R complexes with IL-10 receptor b chain and mediates IL-22 signaling. IL-22 and its receptor activate the JAK-STAT signaling pathway. IL-22R is expressed in normal liver and kidney and in the cell lines HepG2 and TK-10.