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1-Cbz-azetidine-3-carboxylic acid

Selected Variant

HY-W004868-01

Size: 10 g

1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]</sup

Product Specifications

CAS Number

97628-92-7

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-cbz-azetidine-3-carboxylic-acid.html

Purity

99.66

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C(=O)(OCC1=CC=CC=C1)N2CC(C2)C(=O)O

Molecular Formula

C12H13NO4

Molecular Weight

235.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16 (5) :315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Non-cleavable Linker

Available Sizes

Price

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