1-Cbz-azetidine-3-carboxylic acid
Product Specifications
UNSPSC Description
1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]</sup
Target Antigen
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related;PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-cbz-azetidine-3-carboxylic-acid.html
Purity
99.58
Solubility
10 mM in DMSO
Smiles
C(=O)(OCC1=CC=CC=C1)N2CC(C2)C(=O)O
Molecular Weight
235.239
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W004868/1-Cbz-azetidine-3-carboxylic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W004868/1-Cbz-azetidine-3-carboxylic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
97628-92-7
Available Sizes
Curated Selection
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