Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SB-612111 (hydrochloride)

SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 hydrochloride exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1].

Product Specifications

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sb-612111-hydrochloride-1.html

Purity

99.26

Solubility

DMSO : 15.62 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]1C[C@@H](CN2CCC(C3=C(Cl)C=CC=C3Cl)CC2)CCC4=C(C)C=CC=C41.[H]Cl

Molecular Formula

C24H30Cl3NO

Molecular Weight

454.86

References & Citations

[1]Paola F Zaratin, et al. Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (-) -cis-1-methyl-7-[[4- (2,6-dichlorophenyl) piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111 hydrochloride) .J Pharmacol Exp Ther. 2004 Feb;308 (2) :454-61.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NOP Receptor/ORL1

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

PLSCR3 Rabbit Polyclonal Antibody
TA380062 100 µL

PLSCR3 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
TATA binding protein (TBP) Mouse Monoclonal Antibody [Clone ID: 10C1-4F6-4B7]
TA385380 100 µL

TATA binding protein (TBP) Mouse Monoclonal Antibody [Clone ID: 10C1-4F6-4B7]

Sign In for Pricing
View Details
P57 / KIP2 (KP10), CF405S conjugate, 0.1mg/mL
BNC040879-100 1x 100 µL

P57 / KIP2 (KP10), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Human FAM59A (GAREM1) activation kit by CRISPRa
GA112127 1 Kit

Human FAM59A (GAREM1) activation kit by CRISPRa

Sign In for Pricing
View Details
HRP Conjugate Stock Stabilizer, 5X
6173 25 mL

HRP Conjugate Stock Stabilizer, 5X

Sign In for Pricing
View Details
2-Morpholinecarbonitrile
TRC-M296021-500MG 500 mg

2-Morpholinecarbonitrile

Sign In for Pricing
View Details