MK3281
MK3281 (Compound 33) is a non-nucleoside hepatitis C virus (HCV) NS5B polymerase inhibitor, with an EC50 of 28 nM for gt1a[1].
Product Specifications
CAS Number
886041-60-7
UNSPSC
12352005
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mk3281.html
Smiles
CN(C)CCN([C@@H]1CN2C(C3=CC=CC=C3OC1)=C(C4CCCCC4)C5=CC=C(C(O)=O)C=C52)C
Molecular Formula
C29H37N3O3
Molecular Weight
475.62
References & Citations
[1]Narjes F, et al. Discovery of (7R) -14-cyclohexyl-7-{[2- (dimethylamino) ethyl] (methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase. J Med Chem. 2011 Jan 13;54 (1) :289-301.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
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