NLRP3-IN-57
NLRP3-IN-57 (compound 5) inhibits the NLRP3 inflammasome, thereby reducing IL-1β levels in LPS plus Nigericin-induced THP-1 macrophages.[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-57.html
Smiles
COC(C)(/C=C/C/C(C)=C/C[C@@H]1C[C@]2(C(C(C(C3=CC(O)=C(C=C3)O)=O)=C([C@](C2=O)([C@]1(CC/C=C(C)/C)C)C/C=C(C)\C)O)=O)C/C=C(C)\C)C
Molecular Formula
C44H60O7
Molecular Weight
700.94
References & Citations
[1]Hu XY, et al. Anti-inflammatory bicyclic polyprenylated acylphloroglucinols with diverse architectures including an unprecedented 6/6/6 tricyclic core from Garcinia yunnanensis. Bioorg Chem. 2024 Dec;153:107864.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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