Diuron

Diuron is an orally active phenylurea herbicide. Diuron inhibits photosynthesis in plants by blocking the formation of ATP and NADH. Diuron increases the production of ROS. Diuron increases expression of p53 in certain cell lines. Diuron has herbicidal activity against annual and perennial broadleaf weeds and grass weeds. Diuron promotes DMBA/BBN-induced bladder cancer. Diuron can be used in breast cancer research[1][2][3][4][5][6].

Product Specifications

CAS Number

[330-54-1]

UNSPSC

12352005

Hazard Statement

H302, H351, H373, H410

Target

Herbicide; MDM-2/p53; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/diuron.html

Concentration

10mM

Purity

99.08

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C)C

Molecular Formula

C9H10Cl2N2O

Molecular Weight

233.10

Precautions

H302, H351, H373, H410

References & Citations

[1]Huovinen M, et al. Toxicity of diuron in human cancer cells. Toxicol In Vitro. 2015 Oct;29 (7) :1577-86.|[2]Lundegårdh H. THE INFLUENCE OF DIURON (3- (3,4-DICHLOROPHENYL) -1,1-DIMETHYLUREA) ON THE RESPIRATORY AND PHOTOSYNTHETIC SYSTEMS OF PLANTS. Proc Natl Acad Sci U S A. 1965 Apr;53 (4) :703-10.|[3]Da Rocha MS, et al. Diuron-induced rat urinary bladder carcinogenesis: mode of action and human relevance evaluations using the International Programme on Chemical Safety framework. Crit Rev Toxicol. 2014 May;44 (5) :393-406.|[4]Chauhan L K S, et al. Diuron-induced cytological and ultrastructural alterations in the root meristem cells ofAllium cepa. Pesticide Biochemistry and Physiology, 1998, 62 (3) : 152-163.|[5]Da Rocha MS, et al. Diuron-induced rat bladder epithelial cytotoxicity. Toxicol Sci. 2012 Dec;130 (2) :281-8.|[6]de Moura NA, et al. Potential effects of the herbicide Diuron on mammary and urinary bladder two-stage carcinogenesis in a female Swiss mouse model. Arch Toxicol. 2010 Feb;84 (2) :165-73.