Multi-target kinase inhibitor 3
Multi-target kinase inhibitor 3 (compund 6i) is a multi-kinase target inhibitor with anticancer activity. Multi-target kinase inhibitor 3 inhibits EGFR, HER2, VEGFR-2, and CDK2 with IC50s of 0.063 μM, 0.054 μM, 0.119 μM, and 0.448 μM, respectively. Multi-target kinase inhibitor 3 has a good inhibitory effect on breast cancer cells MCF-7, with an IC50 of 6.10 μM[1].
Product Specifications
UNSPSC
12352005
Target
CDK; EGFR; VEGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/multi-target-kinase-inhibitor-3.html
Smiles
O=C(C(N1)=CC2=C1C=CC=C2)NC3=NC(CC(N/N=C/C4=CC=C(N(C)C)C=C4)=O)=CS3
Molecular Formula
C23H22N6O2S
Molecular Weight
446.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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