CD31 / PECAM-1 (Endothelial Cell Marker) (1A10), CF405S conjugate, 0.1mg/mL
CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.
Product Specifications
CAS Number
9007-83-4
Synonyms
EndoCAM; PECA1; Platelet Endothelial Cell Adhesion Molecule 1; GPIIA'
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
PECAM1
Gene ID
5175
NCBI Gene ID
376675 & 514412
UniProt
P16284
Swiss Prot
P16284
Host
Mouse
Species Reactivity
Human
Reactivity
CD31|PECAM-1
Immunogen
Prokaryotic recombinant fusion protein corresponding to a portion of the extracellular domain downstream of the signal sequence of the CD31 (PECAM-1)
Target Antigen
CD31 | PECAM-1
Clonality
Monoclonal
Clone
1A10
Type
Primary
Source
Animal
Origin
Animal
Field of Research
Angiogenesis, Cancer
Positive Control
THP-1, Jurkat cells. Tonsil or Angiosarcoma.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
~100 kDa (endothelium) ; ~130 kDa (platelets)
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG1, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF405S
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