(2Z,3Z)-U0126
Product Specifications
UNSPSC Description
(2Z,3Z)-U0126 is a selective inhibitor of MEK1 and MEK2, demonstrating potent antiinflammatory effects by noncompetitively inhibiting AP-1 transcriptional activity with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. (2Z,3Z)-U0126 also inhibits anchorage-independent growth of Ki-ras-transformed rat fibroblasts by blocking both the extracellular signal-regulated kinase and mammalian target of rapamycin pathways. Additionally, (2Z,3Z)-U0126 can undergo isomerization and cyclization, resulting in various products that show reduced affinity for MEK and diminished AP-1 inhibition compared to the parent compound.
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2z-3z-u0126.html
Smiles
NC(C=CC=C1)=C1S/C(N)=C(C#N)/C(C#N)=C(N)/SC2=C(C=CC=C2)N
Molecular Weight
380.49
References & Citations
[1]MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12031B/2Z-3Z-U0126-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12031B/
Clinical Information
No Development Reported
CAS Number
218601-62-8
Curated Selection
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