Corynoxine B (Standard)
Corynoxine B Standard is an analytical standard for Corynoxine B. This product is intended for research and analytical applications. Corynoxine B is an alkaloid-type autophagy inducer and α-synuclein aggregation inhibitor that ameliorates Mn-induced dysregulation of autophagy and enhances the clearance of α-synuclein (α-syn) in Parkinson's disease mice[1][2][3][4].
Product Specifications
CAS Number
17391-18-3
UNSPSC
12352005
Target
Reference Standards; α-synuclein
Type
Reference Standards
Related Pathways
Neuronal Signaling; Others
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/corynoxine-b-standard.html
Smiles
O=C(NC1=C2C=CC=C1)[C@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@H](CC)C4)([H])N4CC3
Molecular Formula
C22H28N2O4
Molecular Weight
384.47
References & Citations
[1]Yan D, et al. Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells. Food Chem Toxicol. 2019 Feb;124:336-348.|[2]Song JX, et al. HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy. 2014 Jan;10 (1) :144-54. doi: 10.4161/auto.26751. Epub 2013 Jan 1. Erratum in: Autophagy. 2015;11 (9) :1708.|[3]Zhu Q, et al. Corynoxine B targets at HMGB1/2 to enhance autophagy for α-synuclein clearance in fly and rodent models of Parkinson's disease. Acta Pharm Sin B. 2023 Jun;13 (6) :2701-2714.|[4]Chen L, et al. Corynoxine Protects Dopaminergic Neurons Through Inducing Autophagy and Diminishing Neuroinflammation in Rotenone-Induced Animal Models of Parkinson's Disease. Front Pharmacol. 2021 Apr 13;12:642900.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Isoform
α-synuclein Aggregation
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