VK-28

VK-28, a brain-permeable iron chelator, inhibits both basal and Fe/ascorbate-induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 μM. VK-28 exhibits significant neuroprotective effects on ICV-6-OHDA. VK-28 can be used for the research of Parkinson’s disease and other neurodegenerative diseases[1].

Product Specifications

CAS Number

[312611-92-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vk-28.html

Purity

97.17

Solubility

10 mM in DMSO

Smiles

OCCN1CCN(CC1)CC2=C3C=CC=NC3=C(C=C2)O

Molecular Formula

C16H21N3O2

Molecular Weight

287.36

Precautions

H302, H315, H319

References & Citations

[1]Shachar DB, et al. Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats. Neuropharmacology. 2004 Feb;46 (2) :254-63.