GR-46611
GR-46611 is a 5-HT1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia[1][3].
Product Specifications
CAS Number
185259-85-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gr-46611.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCC1=CC=C(OC)C=C1)/C=C/C2=CC3=C(NC=C3CCN(C)C)C=C2
Molecular Formula
C23H27N3O2
Molecular Weight
377.48
Precautions
H302, H315, H319, H335
References & Citations
[1]Paul G Hatini, et al. A 5-HT 1D -receptor agonist protects Dravet syndrome mice from seizure and early death. Eur J Neurosci. 2020 Nov;52 (10) :4370-4374. |[2]C Sibella-Argüelle, et al. The proliferation of human T lymphoblastic cells induced by 5-HT1B receptors activation is regulated by 5-HT-moduline. C R Acad Sci III. 2001 Apr;324 (4) :365-72. |[3]Baojun Gu, et al. Inhibition of bladder activity by 5-hydroxytryptamine1 serotonin receptor agonists in cats with chronic spinal cord injury. J Pharmacol Exp Ther. 2004 Sep;310 (3) :1266-72. |[4]M Skingle, et al. Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig. J Psychopharmacol. 1994 Jan;8 (1) :14-21.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3
Available Sizes
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