N-Despropyl Ropinirole

N-Despropyl Ropinirole (SKF-104557) is an active metabolite of the dopamine D2 receptor agonist Ropinirole (HY-B0623) . N-Despropyl Ropinirole is a full agonist at human D2 and D3 receptors. N-Despropyl Ropinirole is a partial agonistof the hD4 receptor[1].

Product Specifications

CAS Number

[106916-16-9]

Product Name Alternative

SKF-104557

UNSPSC

12352005

Hazard Statement

H302

Target

Dopamine Receptor; Drug Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-despropyl-ropinirole.html

Solubility

10 mM in DMSO

Smiles

CCCNCCC1=C2CC(NC2=CC=C1)=O

Molecular Formula

C13H18N2O

Molecular Weight

218.29

Precautions

P264-P270-P330-P501

References & Citations

[1]Coldwell MC, et al. Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2 (long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1999 Aug;127 (7) :1696-702.