LasR antagonist 1
LasR antagonist 1 (Compound 7) is an antagonist for LasR with an IC50 of 0.4 μM, that modulates the quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa[1].
Product Specifications
CAS Number
1421464-74-5
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lasr-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC#CCOC1=CC(C(F)(F)F)=CC=C1)CC2=NOC3=C2C=CC=C3
Molecular Formula
C20H15F3N2O3
Molecular Weight
388.34
References & Citations
[1]Manson DE, Ananiev GE, Guo S, Ericksen SS, Santa EE, Blackwell HE. Abiotic Small Molecule Inhibitors and Activators of the LasR Quorum Sensing Receptor in Pseudomonas aeruginosa with Potencies Comparable or Surpassing N-Acyl Homoserine Lactones. ACS Infect Dis. 2024 Mar 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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